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KMID : 1094020110280050522
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Journal of Veterinary Clinics
2011 Volume.28 No. 5 p.522 ~ p.525
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Malignant Retroperitoneal Paraganglioma in a Siberian Tiger
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Shin Sang-Kyung
Park Byung-Min
Youm So-Young
Kim Tae-Wang
Na Ki-Jeong
Ahn Byeong-Woo
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Abstract
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A 14 year old female Siberian tiger presented for postmortem examination. A large mass attached to sublumbar area was found to be circumscribing aorta with metastases to mesenteric lymph nodes, uterus, kidney, adrenal gland, lung and thymus. The tumor cells were arranged in clusters or nests separated by well-developed fibrovascular stroma. The individual cells were plump and polygonal with granular eosinophilic cytoplasms and had distinct cell borders. The tumor cells were positive for synaptophysin, chromogranin A and neuron-specific enolase, and negative for cytokeratins, S100 and glial fibrillary acidic protein. The primary tumor was diagnosed as a malignant retroperitoneal paraganglioma.
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KEYWORD
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Siberian tiger, paraganglioma, chromogranin A, neuron-specific enolase, synaptophysin
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